Shimadzu CTO-40C CL Instruction Manual
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Shimadzu CTO-40C CL Instruction Manual

Column oven for shimadzu liquid chromatograph
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228-97203A
Jun. 2022
Column Oven
For Shimadzu Liquid Chromatograph
CTO-40C CL
Instruction Manual
Read this manual thoroughly before you use the product.
Keep this manual for future reference.

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Summary of Contents for Shimadzu CTO-40C CL

  • Page 1 228-97203A Jun. 2022 Column Oven For Shimadzu Liquid Chromatograph CTO-40C CL Instruction Manual Read this manual thoroughly before you use the product. Keep this manual for future reference.
  • Page 2 This page is intentionally left blank.
  • Page 3 Shimadzu representative to request a replacement. • To ensure safe operation, read the accompanying booklet "Safety Guideline" before using the product. • To ensure safe operation, contact your Shimadzu representative if product installation, adjustment, re-installation (after the product is moved), or repair is required.

  • Page 4: Introduction

    • All rights are reserved, including those to reproduce this manual or parts thereof in any form without permission from Shimadzu Corporation. • Prominence, Nexera, and LabSolutions are trademarks of Shimadzu Corporation. Windows is a registered trademark of Microsoft Corporation in the United States and/or other countries.

  • Page 5: Electromagnetic Compatibility

    Electromagnetic Compatibility Descriptions in this section apply only to the following model: • 228-65202-55 CTO-40C CL This product complies with European standard EN61326, class B for electromagnetic interference (Emissions) and industrial electromagnetic environment (Immunity).

  • Page 6: Table Of Contents

    [UTILITY] Setting Group VP Functions Screen ..................3.5.1 List of VP Functions ....3.5.2 Product Information Group (PRODUCT INFO) ... 3.5.3 Maintenance Information Group (MAINTENANCE) ..3.5.4 Validation Support Information Group (VALIDATION) ..3.5.5 Calibration Support Information Group (CALIBRATION) CTO-40C CL...
  • Page 7 Leak Sensor Calibration ........Cleaning the Leak Tray ........Replacing the Air Filter ........Cleaning the Exterior ..................4.7.1 Usual cleaning ........4.7.2 Decontamination cleaning Technical Specifications ............ Information Maintenance Parts ..................5.2.1 Consumable Parts ..........5.2.2 Replacement Parts CTO-40C CL...
  • Page 8 Contents Index ............CTO-40C CL...

  • Page 9: Overview

    Overview The Shimadzu CTO-40C CL column oven was developed to maintain the temperature of the LC system column and flow lines at a constant temperature, in order to provide heightened analysis reproducibility and separation performance. The oven is an air-circulated thermostatic chamber for the Shimadzu Liquid Chromatography system. In...

  • Page 10: Component Parts

    Optional Parts Optional parts which can be added to the column oven are listed below. For information about other optional units listed below, contact your Shimadzu representative. For optional parts for the whole LC system, refer to System Guide. For columns, refer to Shimadzu's column catalog.
  • Page 11 The common installation kit is required for FCV installation kit installing the previously listed valves in the 228-72589-41 (CTO-40C) instrument. (Only one unit is required for this instrument.) FCV tubing two-piece kit The tubing kit is required for installing two 228-72437-41 (ID 0.3) columns. CTO-40C CL...
  • Page 12 The tubing kit is required for installing two to 228-72437-44 (ID 0.1) six columns. The tubing kit is required for installing two to FCV tubing six-piece kit 228-72437-50 six columns. (This Nexlock tubing comes with (ID 0.1 300 mm Nexlock) finger tight fittings.) CTO-40C CL...
  • Page 13 The high performance mixer is intended MIXER MR 300 LPGE exclusively for low pressure gradient analysis with an internal capacity of 300 μL, where (With a mixer detection 228-72653-42 device) stainless steel is used for the wetted part material. CTO-40C CL...

  • Page 14: Parts Identification And Function

    Note that, with a system controller CBM-40 CL connected, the switch does not illuminate and the operation to the switch is ignored. Left door The door of the column temperature control part. Open the door when setting a column. Right door CTO-40C CL...
  • Page 15 The right and left doors have a built-in sensor. Opening the door during temperature control causes the control to be stopped and the [DOOR] indicator on the display area to blink. Closing the door causes the temperature control to be resumed. CTO-40C CL...

  • Page 16: Interior

    Used for fixing tubes. Thermosensor The sensor is for temperature measurement. Gas sensor The sensor detects organic solvent vapors. Liquid leak sensor The sensor detects leakage of aqueous solvent. The connector is for a column management device [CMD1] connector (CMD) (optional). CTO-40C CL...

  • Page 17: Back

    (power button) of the system controller to turn ON/OFF the power from the front of the instrument. If the instrument is not used for a long time, turn off the main power switch. Before turning off the main power switch, be sure to turn OFF the power using the power button. CTO-40C CL...

  • Page 18: Name And Functions Of The Operation Panel

    Illuminates when controlled by the system controller. • Blue: analysis in progress • Green: analysis ready (Temperature control stabilized) • Yellow: preparation for analysis in progress (Temperature Status LED control yet to be stabilized) • Red: error • Orange: sleep mode CTO-40C CL...
  • Page 19 Temperature control start/stop, and time program start/stop can be performed directly. Direct key "2.4.2 Operation Area" P.13 *1 There is the power button in the lower left in the front of this instrument, not on the operation panel. CTO-40C CL...

  • Page 20: Display Area

    Blinks when the front door of the oven unit is opened. When the door is open, the temperature control is paused. DOOR When the oven temperature is 60 °C or higher, a warning message is displayed. Closing the door clears the warning message and resumes the temperature control. CTO-40C CL...

  • Page 21: Operation Area

    • To delete a line of the displayed time program while creating it. [Enter] Enter key Confirms input values of the setting items. [↑][→] Arrow keys Switches the display screen. [↓][←] [·] to [9] Numeric keys Inputs values for the setting items. CTO-40C CL...
  • Page 22 Description Acceptable part of [↑] key input. Acceptable part of [→] key input. Acceptable part of [↓] key input. Acceptable part of [←] key input. CTO-40C CL...

  • Page 23: Settings For The Basic Operation

    Press [→] three times. The [PARAMETER] setting group of the [FUNCTION] setting group is selected and then the [SET TEMP] screen is displayed. Press [Enter]. The cursor starts blinking and activates the numeric keypad. Now the values can be entered. CTO-40C CL...
  • Page 24 Users can change the setting so that temperature control is started by only pressing [OVEN] without the confirmation screen displayed. "Setting the direct key mode《DIRECT KEY MODE》" P.30 CTO-40C CL...
  • Page 25 To stop the temperature control, press [OVEN]. The confirmation screen is displayed. Pressing [Enter] returns the display to the original state and the temperature control stops. Beware of burns when the operating temperature is high (approx. 60 °C or higher). CTO-40C CL...

  • Page 26: Types Of Screens

    [FUNCTION] or VP functions screen [VP]. Move the cursor to the desired option with [↓] or [↑] and press [→] to display the screen. Press [←] to return to the previous screen. Press [CE] to return to the initial screen. CTO-40C CL...

  • Page 27: Monitoring Screens

    Displaying the detected concentration values of the liquid leak sensor and the gas sensor《LEAK SENSOR LEVEL》 Displays the detected concentration values of the liquid leak sensor and the gas sensor. CTO-40C CL...

  • Page 28: Auxiliary Functions Screen (Function)

    6-position valve: 1 to 6 Do not change the factory default value. n [SYSTEM] setting group Name Description Remark Ref. Initial value: 0 Selects independent operation or LOCAL MODE Set value: P.24 control via system controller. 0: Remote 1: Local CTO-40C CL...
  • Page 29 Set value: 0 to 3 Initial value: 0 ACTIVE Sets the active preheater (optional). Set value: P.28 PREHEATER 0: Off 1: On Displays or sets the volume of the MIXER VOL P.28 connected gradient mixer (optional). CTO-40C CL...
  • Page 30 Specifies whether to display the DIRECT KEY Set value: confirmation screen when the P.30 MODE 0: Display 1: Do not direct key is operated. display n [EDIT] group Use this group to create a time program. "3.6 Creating Time Program" P.43 CTO-40C CL...

  • Page 31: Parameter] Setting Group

    Setting the flow line of the automatic column switch valve 1 (at the left part)《VALVE1 (LEFT)》 n Setting the flow line of the automatic column switch valve 2 (at the right part) 《VALVE2 (RIGHT)》 Input the value with the numeric keypad and press [Enter]. CTO-40C CL...

  • Page 32: System] Setting Group

    Setting the Power Button《POWER BUTTON》 Not used in CL model. Do not change the factory default value. Sets the power button on the front of the instrument. Input the value with the numeric keypad and press [Enter]. CTO-40C CL...
  • Page 33 Set Value Function The EVENT1 output is controlled with the [EVENT1] set value. The EVENT1 output is used as a start signal of a time program. If the [SELECT EVENT1] function is used, the corresponding [EVENT1] parameter is disabled. CTO-40C CL...
  • Page 34 Select "Force ON" for a high-sensitive analysis that can be affected by this temporary change. n Setting the temperature ready check《READY CHECK》 Sets whether to wait for displaying [READY] until the oven temperature stabilizes at the set temperature or not. CTO-40C CL...
  • Page 35 Reduces dispersion in temperature inside the oven when the set temperature is high. *1 For analysis systems with an electric conductivity detector or differential refractometer which are susceptible to wind inside the oven, it is recommended to use the setting "3: High". CTO-40C CL...
  • Page 36 Input the value with the numeric keypad and press [Enter]. A mixer volume is used for calculating the gradient delay time of the analysis system. When no mixer information device is connected, the panel displays [Not Identify]. CTO-40C CL...

  • Page 37: Utility] Setting Group

    Only the alarm sound that goes off when an error occurs is activated. All the buzzer sounds are deactivated. n Setting the buzzer volume《VOLUME》 Sets the buzzer sound level. A larger setting value increases the sound level. Input the value with the numeric keypad and press [Enter]. CTO-40C CL...
  • Page 38 Input the value with the numeric keypad and press [Enter]. Set Value Function Displays the confirmation screen. (Initial value). The relevant operation is immediately executed without the confirmation screen displayed. Displaying the confirmation screen helps prevent improper operations. CTO-40C CL...

  • Page 39: Vp Functions Screen

    PART REPLACEMENT Enter the new part after replacing an old part. P.34 MAINTENANCE LOG Displays the maintenance log. P.34 Displays the log of password change, parameter reset, OPERATION LOG P.35 etc. ERROR LOG Displays the error log. P.35 CTO-40C CL...

  • Page 40: Product Information Group (Product Info)

    *1 In the calibration support group, an invalid password prevents the user from going further than [OPERATION MODE] even if the user presses [Enter]. 3.5.2 Product Information Group (PRODUCT INFO) The group is relevant to information of the instrument. n Displaying the serial number《SERIAL NUMBER》 Displays the serial number of the instrument. CTO-40C CL...

  • Page 41: Maintenance Information Group (Maintenance)

    For a valve for LC-40 CL series, the number is increased every time the position is rotated by an angle equivalent to 120° (0 -> 1 -> 0 in case of 2-position valves and 1 -> 3 or 1 -> 2 -> 1 in case of 6-position valves). CTO-40C CL...
  • Page 42 After pressing [→], press [↓] several times to display the replaced parts in order. The example indicates that the rotor seal of the automatic column switch valve 1 was replaced on May 12, 2018. CTO-40C CL...

  • Page 43: Validation Support Information Group (Validation)

    When the instrument is controlled by a system controller, the date is automatically transmitted during link-up. The date display returns to the initial value [00-00-00] when the power is turned OFF. When the power is OFF by using (power button), the setting is not returned. CTO-40C CL...
  • Page 44 [Enter]. Use the syringe (part No. 228-66048) attached to the liquid delivery unit, etc. Wait for approximately 30 seconds at maximum. The diagnosis result is displayed. In case of [NO GOOD], see "4.4 Leak Sensor Calibration" P.57. CTO-40C CL...
  • Page 45 100 µL (Part No. 670-12554-04 ,etc.). Wait for approximately 30 seconds at maximum. The diagnosis result is displayed. In case of [NO GOOD], see "4.3 Gas Sensor Calibration" P.57. n Checking the temperature control accuracy《TEMPERATURE CHECK》 System Guide "4 Hardware Validation" CTO-40C CL...

  • Page 46: Calibration Support Information Group (Calibration)

    Changing the displayed order of year, month and day《DATE FORMAT》 Changes the displayed order of year, month and day. Input the value with the numeric keypad and press [Enter]. Set Value Format Year, month, and day (YMD) Day, month, and year (DMY) Month, day, and year (MDY) CTO-40C CL...
  • Page 47 When the setting is changed, the change is recorded in the operation log. "Displaying the operation log《OPERATION LOG》" P.35 n Changing the password《PASSWORD SETTING》 Enables change to the password. Press [Enter]. The input screen is displayed. Input the five-digit numbers by using the numeric keypad, and press [Enter]. CTO-40C CL...
  • Page 48 Calibrating the gas sensor《GAS SENS CALIB》 This function is not used in the CL model. Recalibration operation is executed by service personnel. Runs the gas sensor calibration. Adjust it when a gas sensor check results in a fail. CTO-40C CL...
  • Page 49 Setting the estimated replacement time of the stator seals of the automatic column switch valves《VALVE1 STATOR》《VALVE2 STATOR》 Sets the estimated replacement time of the stator seals of the automatic column switch valves installed. Input the value with the numeric keypad and press [Enter]. CTO-40C CL...
  • Page 50 When an automatic column switch valve is not installed, the panel does not display the corresponding data. For a valve for LC-30A series or earlier (FCV-xxAH), the number of uses of the stator seals can not be managed and not displayed. CTO-40C CL...

  • Page 51: Creating Time Program

    Repeats a program the after repeating the LOOP specified number of times 0 to 255 specified number of times. P.49 from the first step. (Setting the value to "0" causes 256 repetitions.) － － STOP Stops the program. P.49 CTO-40C CL...

  • Page 52: Time Program Setting Screen

    When there is no step created in a time program, pressing [↓] or [↑] does not change the screen. Pressing [del] in the screen allows deleting the step displayed. Press [Enter]. This displays the time program setting screen. CTO-40C CL...

  • Page 53: Creating A Time Program

    The command selection screen allows selecting another command with [↓] or [↑]. Press [5], [0], and [Enter]. This sets the temperature setting to 50 °C and finishes setting step 1. If you input an incorrect value, press [del] in the screen, which allows deleting one step. CTO-40C CL...
  • Page 54 Press [6], [0], and [Enter]. This finishes setting step 3. To set step 4 Press [Enter]. This displays the time program setting screen. Set step 4. Set it in the same way as step 1. CTO-40C CL...

  • Page 55: Deleting A Step

    To delete step 2 or a subsequent step, press [↓] or [↑] repeatedly until the desired step is displayed. Press [del]. This deletes the first step of the program and moves the second step up to the first step. CTO-40C CL...

  • Page 56: Starting And Stopping A Time Program

    • Use the [LOOP] command to stop the program after repeating it a specified number of times. The highlight is removed from the [RUN] indicator and the program is stopped. After the program is stopped, the settings are set back to the original values before the program was started. CTO-40C CL...

  • Page 57: Special Commands Used In Time Programs

    Running a time program that has no step of the [STOP] or [LOOP] command causes the program to keep running endlessly even after the command at the last step is executed. CTO-40C CL...

  • Page 58: Connection With The System Controller

    1 and 2, ON/OFF of temperature control, and time program. Additionally, the workstations support column management functions. For details, refer to the instruction manuals of the system controllers and workstations. CTO-40C CL...

  • Page 59: Connection To External Input/Output Terminals

    Description Remark EVENT2 Relay contact outputs. They can be turned on/off The rated values of with a time program or the set values of the the relay contacts are EVENT1 [EVENT] auxiliary function. 30 VDC and 0.2 A. CTO-40C CL...
  • Page 60 The short-circuit time The instrument is set to the error detection status (tc) should satisfy the following. by receiving the external error signal. 0.5 sec < tc < 10 sec COMMON terminal for [OVEN ON], [OVEN OFF], [START] and [ERR]. CTO-40C CL...

  • Page 61: Connection Of Remote Cable

    When using the [EVENT1] or [EVENT2] signal, set [EVENT1] or [EVENT2] and [SELECT EVENT1] or [SELECT EVENT2] in the auxiliary functions. "Setting the EVENT1 output terminal《EVENT1》" P.23 "Setting the EVENT2 output terminal《EVENT2》" P.23 "Setting the Power Button《POWER BUTTON》" P.24 "Setting the function of the EVENT2 output terminal《SELECT EVENT2》" P.26 CTO-40C CL...

  • Page 62: Periodic Inspection And Maintenance

    Periodic Inspection and Maintenance It is necessary to perform periodic inspections of this instrument to ensure its safe use. It is possible to have these periodic inspections performed by Shimadzu service personnel on a contractual basis. For information regarding the maintenance inspection contract, contact your Shimadzu representative.

  • Page 63: Prior To Inspection And Maintenance

    2 Years 3 Years Remark Ref. Maintenance Item 　 　 　 Air filter replacement P.58 Nexera seires System Guid e "4.8.2 Inspection of Temperature Testing Accuracy Temper ature Adjust ment Function" Inspection of Gas Sensor P.37 Inspection of Leak Sensor P.36 CTO-40C CL...

  • Page 64: Check After Inspection And Maintenance

    PARTS MGMT TOOL. "Inputting a replacement part number《PART REPLACEMENT》" P.34 Temperature Accuracy Calibration Re-calibration is required if the temperature accuracy of [TEMPERATURE CHECK] fails the temperature control function test of the component validation. "Checking the temperature control accuracy《TEMPERATURE CHECK》" P.37 CTO-40C CL...

  • Page 65: Gas Sensor Calibration

    The first calibration temperature must be no greater than 60 °C and the second calibration temperature must be at least 20 °C higher than the first calibration temperature. Before shipment, the CTO-40C CL is calibrated at 40 °C and 80 °C respectively.

  • Page 66: Cleaning The Leak Tray

    If there is contamination such as crystallized buffer solution, wipe it off with wiper paper soaked in water. Replacing the Air Filter This section explains how to replace the air filter on the right side of the instrument. CTO-40C CL...

  • Page 67: Cleaning The Exterior

    Cleaning the Exterior 4.7.1 Usual cleaning If the exterior of the instrument is dirty, clean it with a dry soft cloth or paper wiper. CTO-40C CL...

  • Page 68: Decontamination Cleaning

    After handling the hazardous substances, using the following procedure. Clean with a cloth soaked in Aqueous ethanol solution (80%) or aqueous sodium hypochlorite solution (0.05%) and wrung tightly. Do not leave metal surfaces wet. This can cause rusting and discoloration. CTO-40C CL...

  • Page 69: Technical Information

    Specification Type Air circulation (Room temperature* - 10 °C) to (100 °C) Room temperature means the ambient temperature at the CTO-40C CL. Temperature control range The upper limit is 85 °C when an automatic column switch valve or column management device (CMD) is connected.

  • Page 70: Maintenance Parts

    Air filter 228-72570-01 Filter only 5.2.2 Replacement Parts Part Name Part No. Remarks Filter holder 228-72234 Tube cap 228-72351 The tube hole cap Guide 228-72350 For tube cap Heat insulation material for the tubing Insulator for pipe 228-23848-01 hole CTO-40C CL...
  • Page 71 VALVE2 ROTOR Input PASSWORD VALVE2 ROTOR USED VALVE2 STATOR VALVE2 STATOR USED KEY CLOSE Version VOLUME VP Functions Screen LEAK SENSOR CHECK LEAK SENSOR LEVEL LINK ADDRESS WAIT TIME LOCAL MODE MAINTENANCE LOG MEMORY CHECK MIXER VOL OPERATION LOG CTO-40C CL...
  • Page 72 This page is intentionally left blank.

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