Pulse Pressure Variation (PPV) is calculated from beat-to-beat arterial pressure values. Pulse pressure
is the difference between the systolic and the diastolic pressure values for a single beat. Pulse pressure
variation is defined as the maximal pressure less the minimum pressure divided by the average of these
The monitor calculates PPV from beat-to-beat values of the arterial pressure selected for CCO.
The circumstances under which the calculation of a PPV value is clinically meaningful, appropriate
and reliable must be determined by a physician.
The clinical value of the derived PPV information must be determined by a physician. According
to recent scientific literature, the clinical relevance of PPV information is restricted to sedated
patients receiving controlled mechanical ventilation and mainly free from cardiac arrhythmia.
PPV calculation may lead to inaccurate values in the following situations:
at respiration rates below 8 rpm
during ventilation with tidal volumes lower than 8 ml/kg
for patients with acute right ventricular dysfunction ("cor pulmonale").
The PPV measurement has been validated only for adult patients
12 Monitoring Cardiac Output